Hello. First of all, I'm not so well versed with Box2d, but I recently started using the built-in physics engine as opposed to simple collision detection using 'containsPoint'.
Using actions such as moveTo and setPosition, will not be impeded by the fact you're using the physics engine. The simplest thing to understand here though, is that, as long as two physics bodies contact, there is a collision.
If you need some Sprites to not interact, it's rather simple. All you need to do is NOT set physics bodies for them.
You'll be able to move Sprites freely even with the physics engine, using actions such as moveTo or setPosition.